Scientist I, Process Development

ArsenalBio, a privately held, clinical-stage programmable cell therapy company engineering advanced CAR T therapies for solid tumors, is seeking a talented Scientist I to work onsite based in our Hayward office.

ArsenalBio’s mission is to develop efficacious and safe cellular therapies for patients with chronic diseases, initially cancer. With our programmable and computationally driven approach, our team is engineering living medicines to attack cancer’s inherent multi-faceted nature and overcome the challenges of addressing solid tumors with cell therapy.

• Independently plan, execute, analyze, and report on experiments to support the development of a GMP process to successfully manufacture T cell therapy products.
• Author and compile documentation (protocols, study reports, etc.) to facilitate transfer of Arsenal Biosciences’s process to manufacturing.
• Organize, communicate, and present complex data sets to key stakeholders and senior management.
• Actively engage in cross-functional collaboration to enable effective project execution and overcome challenges.
• Proactively explore and evaluate emerging technologies to improve and optimize the cell therapy manufacturing process, with a focus on optimizing non-viral gene delivery.

Qualifications and Experience

• PhD, Masters (with 5+ years experience), or Bachelors (with 7+ years experience) in a relevant scientific discipline such as Biotechnology, Bioprocess engineering, Immunology, Molecular Biology, or Biochemistry.
• Proficiency with aseptic mammalian cell culture techniques.
• Experience in immune cell isolation, T cell activation, expansion, and/or gene editing.
• 2+ years of relevant research experience in T cell biology and/or immunotherapy.
• Prior experience in cell therapy and/or process development teams
• Expertise in multi-color flow cytometry analyses including panel design and data analysis.
• Experience in T cell functional assays including cytotoxicity, cytokine/chemokine, and proliferation is a plus.
• Understanding of cGMP environment, Design of Experiment (DOE), and Quality by Design (QBD) principles for process and assay development, qualification, and validation is a plus.
• Demonstrated ability to work well in a highly collaborative team environment and coordinate tasks across multiple projects to meet deadlines.
• Creative approach to problem-solving and ability to think outside the box.